PULLULAN-DOX/PVA-PDMS BIOPOLYMERIC CORE-SHELL NANOFIBERS POTENTIAL FOR DRUG DELIVERY SYSTEMS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F24%3A00012526" target="_blank" >RIV/46747885:24410/24:00012526 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.7216/teksmuh.1496634" target="_blank" >https://doi.org/10.7216/teksmuh.1496634</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7216/teksmuh.1496634" target="_blank" >10.7216/teksmuh.1496634</a>
Alternative languages
Result language
angličtina
Original language name
PULLULAN-DOX/PVA-PDMS BIOPOLYMERIC CORE-SHELL NANOFIBERS POTENTIAL FOR DRUG DELIVERY SYSTEMS
Original language description
In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochloride (DOX) into Pullulan and integrating the core into a polyvinyl alcohol (PVA) and Polydimethoxysilane (PDMS) composite matrix. The incorporation of DOX into the pullulan solution was carried out to take advantage of Pullulan‘s biocompatibility, biodegradability and hydrophilic nature. The hydrophilic nature of PVA can result in rapid drug release, while the hydrophobic nature of PDMS allows for slower drug release. The use of PVA-PDMS polymers together in the shell offers an initial rapid release followed by a prolonged and controlled drug release. This combination is superior to PVA or PDMS in terms of safety, mechanical strength, flexibility, controlled drug release and structural stability. This innovative composite system was designed to optimise DOX‘s controlled release to increase its therapeutic efficacy and reduce systemic toxicity. The kinetics of the drug release was characterised by an initial burst release followed by a sustained release phase, allowing controlled and prolonged release of the chemotherapeutic agent. Our results indicate that the pullulan/PVA-PDMS composite is a promising candidate for practical drug delivery applications, especially in cancer therapy.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tekstil ve Muhendis
ISSN
1300-7599
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
135
Country of publishing house
TR - TURKEY
Number of pages
12
Pages from-to
110-120
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85207036820