Multilayered polyurethane/poly(vinyl alcohol) nanofibrous mats for local topotecan delivery as a potential retinoblastoma treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00571344" target="_blank" >RIV/61389013:_____/23:00571344 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10464838 RIV/00216208:11310/23:10464838 RIV/00064203:_____/23:10464838
Result on the web
<a href="https://www.mdpi.com/1999-4923/15/5/1398/htm" target="_blank" >https://www.mdpi.com/1999-4923/15/5/1398/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pharmaceutics15051398" target="_blank" >10.3390/pharmaceutics15051398</a>
Alternative languages
Result language
angličtina
Original language name
Multilayered polyurethane/poly(vinyl alcohol) nanofibrous mats for local topotecan delivery as a potential retinoblastoma treatment
Original language description
Local chemotherapy using polymer drug delivery systems has the potential to treat some cancers, including intraocular retinoblastoma, which is difficult to treat with systemically delivered drugs. Well-designed carriers can provide the required drug concentration at the target site over a prolonged time, reduce the overall drug dose needed, and suppress severe side effects. Herein, nanofibrous carriers of the anticancer agent topotecan (TPT) with a multilayered structure composed of a TPT-loaded inner layer of poly(vinyl alcohol) (PVA) and outer covering layers of polyurethane (PUR) are proposed. Scanning electron microscopy showed homogeneous incorporation of TPT into the PVA nanofibers. HPLC-FLD proved the good loading efficiency of TPT (≥85%) with a content of the pharmacologically active lactone TPT of more than 97%. In vitro release experiments demonstrated that the PUR cover layers effectively reduced the initial burst release of hydrophilic TPT. In a 3-round experiment with human retinoblastoma cells (Y-79), TPT showed prolonged release from the sandwich-structured nanofibers compared with that from a PVA monolayer, with significantly enhanced cytotoxic effects as a result of an increase in the PUR layer thickness. The presented PUR-PVA/TPT-PUR nanofibers appear to be promising carriers of active TPT lactone that could be useful for local cancer therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutics
ISSN
1999-4923
e-ISSN
1999-4923
Volume of the periodical
15
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
1398
UT code for WoS article
000996838500001
EID of the result in the Scopus database
2-s2.0-85160632886