Hydrogel implants for transscleral diffusion delivery of topotecan: in vivo proof of concept in a rabbit eye model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543808" target="_blank" >RIV/61389013:_____/21:00543808 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10428837 RIV/00216208:11130/21:10428837
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0378517321006372?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517321006372?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2021.120832" target="_blank" >10.1016/j.ijpharm.2021.120832</a>
Alternative languages
Result language
angličtina
Original language name
Hydrogel implants for transscleral diffusion delivery of topotecan: in vivo proof of concept in a rabbit eye model
Original language description
Treatment of retinoblastoma (Rb) has greatly improved in recent years in terms of survival and eye salvage rates, using mainly intra-arterial or intravitreal chemotherapy. However, the treatment of vitreous tumor seeding still represents a challenge and it is of great interest to develop new strategies to deliver pharmacologically sufficient drug amounts to the vitreous humor. In the present work, we present a lens-shaped bi-layered hydrogel implant for delivery of topotecan (TPT) via transscleral diffusion. The implant consists of an inner TPT-loaded poly(2-hydroxyethyl methacrylate) (pHEMA) layer adjacent to the sclera and an outer covering poly(2-ethoxyethyl methacrylate) (pEOEMA) layer impermeable to TPT. TPT-loaded pHEMA samples exhibit long-lasting in vitro cytotoxicity against the Rb cell line Y79. In an in vivo experiment, pHEMA/pEOEMA implants are successfully surgically administered to the posterior segment of rabbit eyes. The determination of TPT pharmacokinetics demonstrates the attainment of promising levels of TPT (10 ng/ml) in vitreous humor 8 h after implant placement. The results from the pilot experiment constitute the proof of principle for the use of the proposed implants as a drug delivery system for the local treatment of intraocular diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
606
Issue of the periodical within the volume
5 September
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
120832
UT code for WoS article
000692244000002
EID of the result in the Scopus database
2-s2.0-85109689036