Interaction of nanostructured TiO2 biointerfaces with stem cells and biofilm-forming bacteria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F17%3A63517012" target="_blank" >RIV/70883521:28610/17:63517012 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.msec.2017.03.174" target="_blank" >http://dx.doi.org/10.1016/j.msec.2017.03.174</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2017.03.174" target="_blank" >10.1016/j.msec.2017.03.174</a>

Result language

angličtina

Original language name

Interaction of nanostructured TiO2 biointerfaces with stem cells and biofilm-forming bacteria

Original language description

Nanostructured TiO2 nanotubes (NTs) of diameters from 15 to 100 nm were fabricated by an electrochemical anodization process. Biofilm-positive strains of Bacillus cereus and Pseudomonas aeruginosa behaved similarly on all TiO2 NTs as well as on native titanium (Ti) foil. The adhesion and growth of mesenchymal stem cells (MSc), embryonic stem cells (ESc), and pure cardiomyocytes derived from ESc exhibited significant differences. MSc as well as ESc were, in contrast to cardiomyocytes, able to adhere, and grow on TiO2 NTs. A correlation between NTs diameter and cell behaviour was however observed in the case of MSc and ESc. MSc were not in a physiological state in the case of 100 nm TiO2 NTs, while ESc were not able to grow on 15 nm TiO2 NTs. It can be stated that these differences can be assigned to different diameters of the NTs but not to the chemistry of the surface. This is the first study describing the comprehensive behaviour of both eukaryotic and prokaryotic cells on TiO2 NTs. On the basis of obtained results, it can be concluded that new generation of medical devices providing selective cell behaviour can be fabricated by optimizing the nanoscale morphology of TiO2.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MATERIALS SCIENCE &amp; ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

ISSN

0928-4931

e-ISSN

—

Volume of the periodical

77

Issue of the periodical within the volume

Neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

500-507

UT code for WoS article

000403381200057

EID of the result in the Scopus database

2-s2.0-85016838751