Hierarchically porous surface of PEEK/nMCS composite created by femtosecond laser and incorporation of resveratrol exhibiting antibacterial performances and osteogenic activity in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F20%3A63526227" target="_blank" >RIV/70883521:28610/20:63526227 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1359836819360147" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359836819360147</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.compositesb.2020.107802" target="_blank" >10.1016/j.compositesb.2020.107802</a>

Result language

angličtina

Original language name

Hierarchically porous surface of PEEK/nMCS composite created by femtosecond laser and incorporation of resveratrol exhibiting antibacterial performances and osteogenic activity in vitro

Original language description

To further improve the surface properties of polyetheretherketone (PEEK)/nanoporous magnesium calcium silicate (nMCS) composite (PMC), hierarchically porous surface of PMC (PMCF) were created by femtosecond laser, and resveratrol (RV) was incorporated into the porous surface of PMCF (RV@PMCF). Compared to PMC with flat surface, PMCF contained not only two types of micropores with different sizes (around 20 μm and 0.5 μm) but also nanopores (around 4 nm), which exhibited remarkably increase in surface roughness and protein adsorption. In addition, PMCF displayed a slow-release of RV while PMC showed a burst-release of RV into cell cultured medium. Moreover, compared with PMC and PMCF, RV@PMCF with antibacterial performances inhibited the growth of E. coli and S. aureus thanks to the release of RV. In addition, compared with PMC, PMCF and RV@PMCF significantly promoted adhesion and proliferation of rat bone mesenchymal stem cells (BMSC). Furthermore, compared with PMCF, RV@PMCF obviously enhanced the proliferation and osteogenic differentiation as well as bone related genes expressions of BMSC. The results demonstrated that PMCF with hierarchically porous surface and incorporating of RV displayed antibacterial performances and osteogenic activity in vitro, Therefore, as a drug-loaded implant, RV@PMCF with good cytocompatibility would have a big potential for applications in orthopaedic fields.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Project

<a href="/en/project/LO1504" target="_blank" >LO1504: Centre of Polymer Systems Plus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Composites Part B-Engineering

ISSN

1359-8368

e-ISSN

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Volume of the periodical

186

Issue of the periodical within the volume

Neuveden

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000518706900028

EID of the result in the Scopus database

2-s2.0-85078844519