Antibacterial porous systems based on polylactide loaded with amikacin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63558678" target="_blank" >RIV/70883521:28610/22:63558678 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1420-3049/27/20/7045" target="_blank" >https://www.mdpi.com/1420-3049/27/20/7045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules27207045" target="_blank" >10.3390/molecules27207045</a>
Alternative languages
Result language
angličtina
Original language name
Antibacterial porous systems based on polylactide loaded with amikacin
Original language description
Three porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity. Depending on their actual composition, the materials exhibited varied efficacy for drug loading, as follows: 25.4 ± 2.2 μg/mg (matrices with 0.05% w/v of chitosan), 93 ± 13 μg/mg (with 0.08% w/v SiO2 amikacin modified nanoparticles), and 96 ± 34 μg/mg (matrices without functional additives). An in vitro study confirmed extended release of the drug (amikacin, over 60 days), carried out in accordance with the mathematical Kosmyer–Pepas model for all the materials tested. The matrices were also evaluated for their effectiveness in inhibiting the growth of bacteria such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Concurrent research was conducted on the transdermal absorption, morphology, elemental composition, and thermogravimetric properties of the released drug.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
20
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
nestrankovano
UT code for WoS article
000873039400001
EID of the result in the Scopus database
2-s2.0-85140908933