Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63558879" target="_blank" >RIV/70883521:28610/22:63558879 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/22:00128756
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861722005665?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861722005665?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2022.119661" target="_blank" >10.1016/j.carbpol.2022.119661</a>

Result language
angličtina
Original language name
Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative
Original language description
Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of -COOH groups at C2 and C3 carbons of oxidized ?-glucuronic acid units, is investigated. The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties. Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines. DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy. DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/GA20-28732S" target="_blank" >GA20-28732S: Colloidal systems for topical formulations. Pickering emulsions and polymer based colloids.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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