Graphene oxide produced from spent coffee grounds in electrospun cellulose acetate scaffolds for tissue engineering applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63567318" target="_blank" >RIV/70883521:28610/23:63567318 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2352492823006657?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352492823006657?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mtcomm.2023.105974" target="_blank" >10.1016/j.mtcomm.2023.105974</a>

Result language

angličtina

Original language name

Graphene oxide produced from spent coffee grounds in electrospun cellulose acetate scaffolds for tissue engineering applications

Original language description

Biomaterials are widely used in the field of tissue engineering as coatings, scaffolds, or injectables. Since these materials need to be compatible with the biological conditions of the human body, improving the sources and methods of production for biomaterials call for continuous innovation. In this study, fibers were electrospun from cellulose acetate (CA) polymer solution using graphene oxide (GO) as a filler, for bone tissue engineering applications. The GO was synthesized from spent coffee grounds, a carbonaceous source that is discarded abundantly. A non-energy-intensive methodology was used for the production. CA with 5 wt% of GO nanoparticles was dissolved in a dimethylacetamide and acetone solvent mixture to produce the polymer solution. The nanofibrous scaffolds were tested for their morphological and mechanical properties as well as their biocompatibility. Scanning electron microscopy (SEM) results showed that electrospinning produced smooth nanofibers with very few beads. Fiber diameters decreased with the addition of GO nanoparticles. Mechanical testing showed that modified CA scaffolds exhibited an improved tensile strength of 115.75 kPa on average compared to the pristine ones. In addition, a cell culture study revealed that using graphene oxide as a modifier of the matrix is non-toxic and promoted cell growth. The oxygen-rich and hydrophilic nature of GO played a role in the biocompatibility of the produced fibers. In general, this study showed that agro-residual biomass can be used to produce and modify biomaterials. This aspect contributes to research on sustainable bio-composites and the effort in environmental conservation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Today Communications

ISSN

2352-4928

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

Neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

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UT code for WoS article

001042295600001

EID of the result in the Scopus database

2-s2.0-85152899831