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The importance of time: time delays in acute stroke

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F16%3A00011385" target="_blank" >RIV/75010330:_____/16:00011385 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/16:43911416

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0010865016300170" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0010865016300170</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.crvasa.2016.03.002" target="_blank" >10.1016/j.crvasa.2016.03.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The importance of time: time delays in acute stroke

  • Original language description

    Endovascular treatment (EVT) of severe acute ischemic stroke (AIS) determined by large vessel occlusion (LVO) is effective and safe. Debate still goes on especially about time importance and utilization of advanced penumbra imaging at the expense of losing valuable minutes. We did a meta-analysis focused on time of randomized clinical trials (RCTs) that started to use methodically the new-tech stent retrievers. The chosen time interval was onset-groin time (from last seen well to sheath insertion in the cathlab). Primary outcome was good functional outcome (mRS of 0-2) at 90 days, secondary outcomes were mortality at 90 days and symptomatic intra-cerebral hemorrhage (sICH). Furthermore, we did a sub-analysis of the EVT patients to find a correlation between faster times and outcomes. We did the same sub-analysis including also single-arm registries that used modern stent retrievers. Totally data from 1287 patients (5 RCTs) were analyzed, whose 634 EVT patients were divided into two groups based on time (faster/slower than 240 min). emphasizing how delays could even worsen AIS. This meta-analysis supports the "Time is brain" strategy in treatment of acute ischemic stroke. In general, fast endovascular treatment (groin puncture within < 4 h) signifi cantly improves patients' outcomes. Healthcare systems should develop maximal effort to shorten pre-hospital and in-hospital delays in acute stroke patients. The earlier the patient is presenting, the more important is the fast track, offering chance for full neurologic recovery.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cor et Vasa

  • ISSN

    0010-8650

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    234-240

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-84963853539