The importance of time: time delays in acute stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F16%3A00011385" target="_blank" >RIV/75010330:_____/16:00011385 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/16:43911416
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0010865016300170" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0010865016300170</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.03.002" target="_blank" >10.1016/j.crvasa.2016.03.002</a>
Alternative languages
Result language
angličtina
Original language name
The importance of time: time delays in acute stroke
Original language description
Endovascular treatment (EVT) of severe acute ischemic stroke (AIS) determined by large vessel occlusion (LVO) is effective and safe. Debate still goes on especially about time importance and utilization of advanced penumbra imaging at the expense of losing valuable minutes. We did a meta-analysis focused on time of randomized clinical trials (RCTs) that started to use methodically the new-tech stent retrievers. The chosen time interval was onset-groin time (from last seen well to sheath insertion in the cathlab). Primary outcome was good functional outcome (mRS of 0-2) at 90 days, secondary outcomes were mortality at 90 days and symptomatic intra-cerebral hemorrhage (sICH). Furthermore, we did a sub-analysis of the EVT patients to find a correlation between faster times and outcomes. We did the same sub-analysis including also single-arm registries that used modern stent retrievers. Totally data from 1287 patients (5 RCTs) were analyzed, whose 634 EVT patients were divided into two groups based on time (faster/slower than 240 min). emphasizing how delays could even worsen AIS. This meta-analysis supports the "Time is brain" strategy in treatment of acute ischemic stroke. In general, fast endovascular treatment (groin puncture within < 4 h) signifi cantly improves patients' outcomes. Healthcare systems should develop maximal effort to shorten pre-hospital and in-hospital delays in acute stroke patients. The earlier the patient is presenting, the more important is the fast track, offering chance for full neurologic recovery.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cor et Vasa
ISSN
0010-8650
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
234-240
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-84963853539