The Arg753Gln polymorphism of Toll-like receptor 2 has a lower occurrence in patients with syphilis, suggesting its protective effect in Czech and Slovak individuals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013412" target="_blank" >RIV/75010330:_____/21:00013412 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10420375 RIV/00216224:14110/21:00120100
Result on the web
<a href="https://iai.asm.org/content/89/1/e00503-20.abstract" target="_blank" >https://iai.asm.org/content/89/1/e00503-20.abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/IAI.00503-20" target="_blank" >10.1128/IAI.00503-20</a>
Alternative languages
Result language
angličtina
Original language name
The Arg753Gln polymorphism of Toll-like receptor 2 has a lower occurrence in patients with syphilis, suggesting its protective effect in Czech and Slovak individuals
Original language description
Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/NV17-31333A" target="_blank" >NV17-31333A: Development of a new typing scheme for syphilis spirochete, Treponema pallidum subsp. pallidum, preferentially targeting proteome differences</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infection and Immunity
ISSN
0019-9567
e-ISSN
1098-5522
Volume of the periodical
89
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
e00503-20
UT code for WoS article
000600550700003
EID of the result in the Scopus database
2-s2.0-85098603294