Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00013860" target="_blank" >RIV/75010330:_____/22:00013860 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00126377
Result on the web
<a href="https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02057-y" target="_blank" >https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02057-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12931-022-02057-y" target="_blank" >10.1186/s12931-022-02057-y</a>
Alternative languages
Result language
angličtina
Original language name
Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study
Original language description
Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. Methods This prospective population-based cohort includes men and women aged 45-69 years, residents in urban settlements in Czech Republic, Poland, Russia and Lithuania, randomly selected from population registers. The baseline survey in 2002-2005 included 36,106 persons of whom 24,993 met the inclusion criteria. Cox proportional hazards models were used to estimate the hazard ratios of mortality over 11-16 years of follow-up for mild, moderate, moderate-severe and very severe lung function impairment categories. Results After adjusting for covariates, mild (hazard ratio (HR): 1.25; 95% CI 1.15-1.37) to severe (HR: 3.35; 95% CI 2.62-4.27) reduction in FEV1 was associated with an increased risk of death according to degree of lung impairment, compared to people with normal lung function. The association was only slightly attenuated but remained significant after exclusion of smokers and participants with previous history of respiratory diseases. The HRs varied between countries but not statistically significant; the highest excess risk among persons with more severe impairment was seen in Poland (HR: 4.28, 95% CI 2.14-8.56) and Lithuania (HR: 4.07, 95% CI 2.21-7.50). Conclusions Reduced FEV1 is an independent predictor of all-cause mortality, with risk increasing with the degree of lung function impairment and some country-specific variation between the cohorts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Respiratory Research
ISSN
1465-993X
e-ISSN
1465-993X
Volume of the periodical
23
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
140
UT code for WoS article
000803888300002
EID of the result in the Scopus database
2-s2.0-85131007557