All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00013866" target="_blank" >RIV/75010330:_____/22:00013866 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00126691
Result on the web
<a href="https://www.nature.com/articles/s41598-022-17261-5" target="_blank" >https://www.nature.com/articles/s41598-022-17261-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-022-17261-5" target="_blank" >10.1038/s41598-022-17261-5</a>
Alternative languages
Result language
angličtina
Original language name
All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts
Original language description
It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
12959
UT code for WoS article
000833071900069
EID of the result in the Scopus database
2-s2.0-85135156680