The potential for genotoxicity, mutagenicity and endocrine disruption in Triclosan and Triclocarban assessed through a combination of in vitro methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F24%3A00014520" target="_blank" >RIV/75010330:_____/24:00014520 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/24:73626008
Result on the web
<a href="https://www.mdpi.com/2039-4713/14/1/2" target="_blank" >https://www.mdpi.com/2039-4713/14/1/2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jox14010002" target="_blank" >10.3390/jox14010002</a>
Alternative languages
Result language
angličtina
Original language name
The potential for genotoxicity, mutagenicity and endocrine disruption in Triclosan and Triclocarban assessed through a combination of in vitro methods
Original language description
Triclosan and Triclocarban, preservatives widely used in cosmetics and other consumer products, underwent evaluation using a battery of new-approach methodologies in vitro (NAMs). Specifically, the Microplate Ames Test (MPF (TM) Test, Xenometrix, Allschwil, Switzerland) was employed to assess mutagenicity, the Comet assay in vitro on the HaCat cell line and the Mammalian Chromosome Aberration Test were utilized to evaluate genotoxicity, and the XenoScreen (R) YES/YAS assay was applied to investigate endocrine disruption. The chemicals did not exhibit any positive responses for mutagenicity. However, the mammalian chromosome aberration test identified both chemicals as being positive for genotoxicity at 10 mu g/mL. In the Comet assay, the percentage of DNA in the tail significantly increased in a concentration-dependent manner (at 5 and 10 mu g/mL for Triclosan, at 2.5, 5, and 10 mu g/mL for Triclocarban). The positive response depended on the increasing concentration and the duration of exposure. Triclosan, but not Triclocarban in any of the endocrine assays performed, indicated a potential for endocrine activity in the anti-estrogenic and anti-androgenic assays. The positive in vitro results detected were obtained for concentrations relevant to final products. The alarming findings obtained with the use of new-approach methodologies (NAMs) justify the current precautionary regulatory approach, limiting the use of these preservatives.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Xenobiotics
ISSN
2039-4705
e-ISSN
2039-4713
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
15-30
UT code for WoS article
001192950600001
EID of the result in the Scopus database
2-s2.0-85188904430