Sex differences in the association between physical functioning and cognition in two Central European populations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F25%3A00015133" target="_blank" >RIV/75010330:_____/25:00015133 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/25:00142382
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.70325?getft_integrator=clarivate&src=getftr&utm_source=clarivate" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.70325?getft_integrator=clarivate&src=getftr&utm_source=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ene.70325" target="_blank" >10.1111/ene.70325</a>
Alternative languages
Result language
angličtina
Original language name
Sex differences in the association between physical functioning and cognition in two Central European populations
Original language description
Background: Evidence on the relationship between physical and cognitive functions remains inconsistent, and the role of sex differences is underexplored. This study examines the predictive value of a composite Physical Functioning Score (PFS) for cognitive function and assesses sex-specific associations in an Eastern European population. Methods: Data from 7309 participants (mean age 59 +/- 7.3 years) from the Czech Republic and Poland arms of the HAPIEE study were analyzed. PFS was derived from a 23-item measure including activity of daily living (ADL/IADL), grip strength, functional limitations, and physical activity. Cognitive function was assessed using standardized tests of memory, verbal fluency, and speed/concentration. Logistic regression, adjusted for demographic, lifestyle, and health factors, was used to examine the association between PFS and cognitive status. Model performance was evaluated using AUC-ROC and cross-validation. Results: PFS exhibited a dose-dependent association with cognitive impairment (adjusted odds ratios: 1.15 for moderate, 1.79 for low PFS, compared with higher PFS). PFS demonstrated robust predictive ability for cognition (AUC = 0.75). Sex differences were significant: women with moderate PFS had a 44% higher risk of cognitive impairment (OR: 1.44, 95% CI: 1.15-1.79), while those with low PFS had double the risk (OR: 2.28, 95% CI: 1.69-3.08). Associations were weaker in men, even at very low PFS (OR: 1.32, 95% CI: 0.91-1.92). Conclusions: PFS is a practical tool for predicting cognitive decline, with stronger associations in women. Interventions to improve PF may preserve cognitive health, particularly in older women. Longitudinal studies are needed to confirm these findings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neurology
ISSN
1351-5101
e-ISSN
1468-1331
Volume of the periodical
32
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
e70325
UT code for WoS article
001588202300007
EID of the result in the Scopus database
2-s2.0-105015118321