Single-cell gene-expression profiling and its potential diagnostic applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00364328" target="_blank" >RIV/86652036:_____/11:00364328 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1586/ERM.11.60" target="_blank" >http://dx.doi.org/10.1586/ERM.11.60</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1586/ERM.11.60" target="_blank" >10.1586/ERM.11.60</a>

Result language
angličtina
Original language name
Single-cell gene-expression profiling and its potential diagnostic applications
Original language description
Gene-expression profiling has been successfully applied in various diagnostic applications, but its full capacity is yet to be realized. Samples are generally prepared from a mixture of different cells that are present in unknown proportions. Cells are,in many aspects, unique in their characteristics and this heterogeneity confounds the expression profile. The development of new and robust techniques to measure gene expression in single cells opens new avenues in molecular medicine. Today, gene-expression profiles of individual cells can be measured with high precision and accuracy, identifying different cell types as well as revealing heterogeneity among cells of the same kind. Here, we review practical aspects of single-cell gene-expression profiling using reverse transcription quantitative real-time PCR and its potential use in diagnostics
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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