Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00369494" target="_blank" >RIV/86652036:_____/11:00369494 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11095-011-0566-7" target="_blank" >http://dx.doi.org/10.1007/s11095-011-0566-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11095-011-0566-7" target="_blank" >10.1007/s11095-011-0566-7</a>
Alternative languages
Result language
angličtina
Original language name
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
Original language description
Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevanceto protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Research
ISSN
0724-8741
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
35
Pages from-to
2695-2730
UT code for WoS article
000295697700006
EID of the result in the Scopus database
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