Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00369516" target="_blank" >RIV/86652036:_____/11:00369516 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0018232" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0018232</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0018232" target="_blank" >10.1371/journal.pone.0018232</a>
Alternative languages
Result language
angličtina
Original language name
Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma
Original language description
Improved detection methods for diagnosis of malignant mesothelioma (MM) are essential for detection and treatment. miRNAs isolated from fresh-frozen biopsies of MM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Three significantly downregulated miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MM tissues by quantitative RT-PCR. Only miR-126 remained downregulated in the malignant tissues. The performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MM, SMRPs, correlate with subjects at high risk to develop MM.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA204%2F08%2F0811" target="_blank" >GA204/08/0811: Mechanism of ROS generation and mitochondrial permeabilization</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"e18232"
UT code for WoS article
000289058300007
EID of the result in the Scopus database
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