Progress of sperm Izumo1 relocation during spontaneous acrosome reaction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00421166" target="_blank" >RIV/86652036:_____/14:00421166 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/14:10209859

Result on the web

<a href="http://dx.doi.org/10.1530/REP-13-0193" target="_blank" >http://dx.doi.org/10.1530/REP-13-0193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/REP-13-0193" target="_blank" >10.1530/REP-13-0193</a>

Result language

angličtina

Original language name

Progress of sperm Izumo1 relocation during spontaneous acrosome reaction

Original language description

It has been recently shown in mice that sperm undergo acrosome reaction (AR) by passing through cumulus cells, furthermore the acrosome-reacted sperm can bind to zona pellucida, and consequently fertilize the egg. During AR, the relocation of the primaryfusion protein Izumo1 into the equatorial segment is crucial for sperm-egg fusion. There is a high rate of spontaneous AR in rodents, with up to 60% in promiscuous species. The aim of this study was to clarify whether the Izumo1 relocation in sperm after spontaneous and induced AR is the same; and whether there is a correlation between the speed of Izumo1 relocation and species-specific mating behaviour in field mice. Immunofluorescent detection of Izumo1 dynamics during the in vitro capacitation, spontaneous, calcium ionophore and progesterone induced AR was monitored. Our results show that during spontaneous AR there is a clear Izumo1 relocation from the acrosomal cap to the equatorial segment, and further over the whole sperm head.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Reproduction

ISSN

1470-1626

e-ISSN

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Volume of the periodical

147

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

231-240

UT code for WoS article

000330557700012

EID of the result in the Scopus database

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