Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F16%3A00508209" target="_blank" >RIV/86652036:_____/16:00508209 - isvavai.cz</a>
Result on the web
<a href="https://www.wjgnet.com/1948-0210/full/v8/i12/399.htm" target="_blank" >https://www.wjgnet.com/1948-0210/full/v8/i12/399.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4252/wjsc.v8.i12.399" target="_blank" >10.4252/wjsc.v8.i12.399</a>
Alternative languages
Result language
angličtina
Original language name
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment
Original language description
Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage. ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Stem Cells
ISSN
1948-0210
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
28
Pages from-to
399-427
UT code for WoS article
000405404100002
EID of the result in the Scopus database
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