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Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F16%3A00508209" target="_blank" >RIV/86652036:_____/16:00508209 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.wjgnet.com/1948-0210/full/v8/i12/399.htm" target="_blank" >https://www.wjgnet.com/1948-0210/full/v8/i12/399.htm</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4252/wjsc.v8.i12.399" target="_blank" >10.4252/wjsc.v8.i12.399</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

  • Original language description

    Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage. ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    World Journal of Stem Cells

  • ISSN

    1948-0210

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    28

  • Pages from-to

    399-427

  • UT code for WoS article

    000405404100002

  • EID of the result in the Scopus database