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Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00481119" target="_blank" >RIV/86652036:_____/17:00481119 - isvavai.cz</a>

  • Result on the web

    <a href="https://patents.google.com/patent/CN105452265B/en" target="_blank" >https://patents.google.com/patent/CN105452265B/en</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

  • Original language description

    The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivativesnof tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixturen(MitoTAX). Alkyl triphenylphosphonium derivatives oftamoxifen have the general formula (I), where n=8 to 12 and where Z is selectednfrom the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the generalnformula IA, where n = 6 to l 0 and where Z has the above mentioned meaning. These compounds are applicable for the treatment ofnneoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to theninvention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I)nand/or IA or their corresponding salts of tertiary amine.

  • Czech name

  • Czech description

Classification

  • Type

    P - Patent

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Patent/design ID

    CN105452265

  • Publisher

    CN002 -

  • Publisher name

    Patent Office - State Intellectual Property Office of the Peoples` Republic of China (SIPO)

  • Place of publication

    Beijing

  • Publication country

    CN - CHINA

  • Date of acceptance

    May 10, 2017

  • Owner name

    J. Neužil, Biotechnologický ústav AV ČR, v. v. i., Smart Brain s.r.o., KKCG AG

  • Method of use

    A - Výsledek využívá pouze poskytovatel

  • Usage type

    A - K využití výsledku jiným subjektem je vždy nutné nabytí licence