Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level
Result description
he invention relates to new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivatives of tamoxifen, where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixtures (MitoTAX). Alkyl triphenylphosphonium derivatives of tamoxifen have the general formula (I):I,where n=8…12 and Z is selected from the group of organic or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the general formula IA:IAwhere n=6…10 and Z has the above mentioned meaning.These compounds are applicable for the treatment of neoplastic diseases, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases, according to the invention, contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I) and/or IA or their corresponding tertiary amine salts.
Keywords
The result's identifiers
Result code in IS VaVaI
Result on the web
https://worldwide.espacenet.com/patent/search/family/050677895/publication/MD4626C1?q=pn%3DMD4626C1
DOI - Digital Object Identifier
—
Alternative languages
Result language
rumunština
Original language name
Derivaţi de tamoxifen pentru tratamentul afecţiunilor neoplazice, în special cu nivel înalt de proteină HER2
Original language description
Prezenta invenţie se referă la noi izomeri E/Z direcţionaţi mitocondrial ai derivaţilor de trifenilfosfoniu alifatic ai tamoxifenului, în care lanţul alifatic este alchil sau alchenil, şi la sărurile aminice terţiare corespunzătoare ale acestora, şi/sau la amestecurile acestora (MitoTax). Derivaţii de alchil trifenilfosfoniu ai tamoxifenului au formula generală (I):I,în care n = 8…12 şi Z este selectat dintr-o grupă de săruri organice sau anorganice.Derivaţii de alchenil trifenilfosfoniu ai tamoxifenului au formula generală IA:IA,în care n = 6…10 şi Z are semnificaţiile definite mai sus.Aceşti compuşi sunt aplicabili pentru tratamentul bolilor neoplazice, în special al celor cu niveluri înalte de proteină HER2. Medicamentul pentru tratamentul bolilor neoplazice, conform prezentei invenţii, conţine cel puţin un izomer E/Z al derivaţilor de trifenilfosfoniu alifatic ai tamoxifenului cu formula generală (I) şi/sau IA, sau sărurile lor corespunzătoare ale aminelor terţiare.
Czech name
—
Czech description
—
Classification
Type
P - Patent
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
MD4626
Publisher
MD001 -
Publisher name
State Agency on Intellectual Property
Place of publication
Kishinev
Publication country
MD - MOLDOVA, REPUBLIC OF
Date of acceptance
Feb 22, 2019
Owner name
SMART BRAIN, s.r.o., BIOTECHNOLOGICKÝ ÚSTAV AV ČR, v. v. i., NEUŽIL JIŘÍ, KKCG AG
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence
Result type
P - Patent
OECD FORD
Biochemistry and molecular biology
Year of implementation
2019