Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508075" target="_blank" >RIV/86652036:_____/17:00508075 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-017-15475-6" target="_blank" >https://www.nature.com/articles/s41598-017-15475-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-017-15475-6" target="_blank" >10.1038/s41598-017-15475-6</a>

Result language

angličtina

Original language name

Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression

Original language description

Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exosome and exosome-free serum fractions in non-small cell lung cancer (NSCLC) patients at early and advanced stages, and compared with healthy controls. Down-regulation of miR-126 was found in serum of advanced stage NSCLC patients. In healthy controls, circulating miR-126 was equally distributed between exosomes and exosome-free serum fractions. Conversely, in both early and advanced stage NSCLC patients, miR-126 was mainly present in exosomes. Different fractions of miR-126 in circulation may reflect different conditions during tumour formation. Incubation of exosomes from early and advanced NSCLC patients induced blood vessel formation and malignant transformation in human bronchial epithelial cells. On the other hand, exosome-enriched miR-126 from normal endothelial cells inhibited cell growth and induces loss of malignancy of NSCLC cells. These findings suggest a role of exo-miRs in the modulation of the NSCLC microenvironmental niche. Exosome-delivered miRs thus hold a substantial promise as a diagnostics biomarker as well as a personalized therapeutic modality.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

NOV 10 2017

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

15277

UT code for WoS article

000414917800017

EID of the result in the Scopus database

2-s2.0-85033573250