Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508201" target="_blank" >RIV/86652036:_____/17:00508201 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318234" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318234</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/2162402X.2017.1318234" target="_blank" >10.1080/2162402X.2017.1318234</a>
Alternative languages
Result language
angličtina
Original language name
Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells
Original language description
An important question is how chemotherapy may (re-) activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8(+) T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re- engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncoimmunology
ISSN
2162-402X
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
e1318234
UT code for WoS article
000408961700005
EID of the result in the Scopus database
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