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Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508201" target="_blank" >RIV/86652036:_____/17:00508201 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318234" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318234</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/2162402X.2017.1318234" target="_blank" >10.1080/2162402X.2017.1318234</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells

  • Original language description

    An important question is how chemotherapy may (re-) activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8(+) T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re- engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oncoimmunology

  • ISSN

    2162-402X

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    e1318234

  • UT code for WoS article

    000408961700005

  • EID of the result in the Scopus database