Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508206" target="_blank" >RIV/86652036:_____/17:00508206 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/emm2016153" target="_blank" >https://www.nature.com/articles/emm2016153</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/emm.2016.153" target="_blank" >10.1038/emm.2016.153</a>
Alternative languages
Result language
angličtina
Original language name
Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
Original language description
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell-cell communication by transferring nucleic acids and proteins to target cells and tissues. Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental and Molecular Medicine
ISSN
1226-3613
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
JAN 2017
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e285
UT code for WoS article
000393674100005
EID of the result in the Scopus database
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