Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F18%3A00495406" target="_blank" >RIV/86652036:_____/18:00495406 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/18:00495406 RIV/61989592:15110/18:73590654
Result on the web
<a href="http://dx.doi.org/10.18632/aging.101404" target="_blank" >http://dx.doi.org/10.18632/aging.101404</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/aging.101404" target="_blank" >10.18632/aging.101404</a>
Alternative languages
Result language
angličtina
Original language name
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
Original language description
Aging involves tissue accumulation of senescent cells (SC) whose elimination through senolytic approaches may evoke organismal rejuvenation. SC also contribute to aging-associated pathologies including cancer, hence it is imperative to better identify and target SC. Here, we aimed to identify new cell-surface proteins differentially expressed on human SC. Besides previously reported proteins enriched on SC, we identified 78 proteins enriched and 73 proteins underrepresented in replicatively senescent BJ fibroblasts, including L1CAM, whose expression is normally restricted to the neural system and kidneys. L1CAM was: 1) induced in premature forms of cellular senescence triggered chemically and by gamma-radiation, but not in Ras-induced senescence, 2) induced upon inhibition of cyclin-dependent kinases by p16(INK4a), 3) induced by TGFbeta and suppressed by RAS/MAPK(Erk) signaling (the latter explaining the lack of L1CAM induction in RAS-induced senescence),and 4) induced upon downregulation of growth-associated gene ANT2, growth in low-glucose medium or inhibition of the mevalonate pathway. These data indicate that L1CAM is controlled by a number of cell growth-and metabolism-related pathways during SC development. Functionally, SC with enhanced surface L1CAM showed increased adhesion to extracellular matrix and migrated faster. Our results provide mechanistic insights into senescence of human cells, with implications for future senolytic strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LM2011024" target="_blank" >LM2011024: EATRIS-CZ - Enhancement and Connection of the Czech Translational Medicine Infrastructures to the European Advanced Translational Medicine Infrastructure (EATRIS)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aging
ISSN
1945-4589
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
29
Pages from-to
434-462
UT code for WoS article
000428889100016
EID of the result in the Scopus database
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