Molecular Aspects of the Development and Function of Auditory Neurons
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F21%3A00538962" target="_blank" >RIV/86652036:_____/21:00538962 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/1/131" target="_blank" >https://www.mdpi.com/1422-0067/22/1/131</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22010131" target="_blank" >10.3390/ijms22010131</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Aspects of the Development and Function of Auditory Neurons
Original language description
This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA20-06927S" target="_blank" >GA20-06927S: The role of NEUROD1 and ISL1 in neuronal development of the inner ear</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
131
UT code for WoS article
000606047300001
EID of the result in the Scopus database
2-s2.0-85098695040