Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F24%3A00604158" target="_blank" >RIV/86652036:_____/24:00604158 - isvavai.cz</a>
Result on the web
<a href="https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-081423-093942" target="_blank" >https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-081423-093942</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1146/annurev-neuro-081423-093942" target="_blank" >10.1146/annurev-neuro-081423-093942</a>
Alternative languages
Result language
angličtina
Original language name
Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain
Original language description
Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA23-05963S" target="_blank" >GA23-05963S: Transcriptional and epigenetic regulation of auditory neuron development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annual Review of Neuroscience
ISSN
0147-006X
e-ISSN
1545-4126
Volume of the periodical
47
Issue of the periodical within the volume
February 15
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
1-20
UT code for WoS article
001293203100001
EID of the result in the Scopus database
2-s2.0-85197356232