NEUROD1 Is Required for the Early alpha and beta Endocrine Differentiation in the Pancreas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F21%3A00548733" target="_blank" >RIV/86652036:_____/21:00548733 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1422-0067/22/13/6713" target="_blank" >https://www.mdpi.com/1422-0067/22/13/6713</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms22136713" target="_blank" >10.3390/ijms22136713</a>

Result language

angličtina

Original language name

NEUROD1 Is Required for the Early alpha and beta Endocrine Differentiation in the Pancreas

Original language description

Diabetes is a metabolic disease that involves the death or dysfunction of the insulin-secreting beta cells in the pancreas. Consequently, most diabetes research is aimed at understanding the molecular and cellular bases of pancreatic development, islet formation, beta-cell survival, and insulin secretion. Complex interactions of signaling pathways and transcription factor networks regulate the specification, growth, and differentiation of cell types in the developing pancreas. Many of the same regulators continue to modulate gene expression and cell fate of the adult pancreas. The transcription factor NEUROD1 is essential for the maturation of beta cells and the expansion of the pancreatic islet cell mass. Mutations of the Neurod1 gene cause diabetes in humans and mice. However, the different aspects of the requirement of NEUROD1 for pancreas development are not fully understood. In this study, we investigated the role of NEUROD1 during the primary and secondary transitions of mouse pancreas development. We determined that the elimination of Neurod1 impairs the expression of key transcription factors for alpha- and beta-cell differentiation, beta-cell proliferation, insulin production, and islets of Langerhans formation. These findings demonstrate that the Neurod1 deletion altered the properties of alpha and beta endocrine cells, resulting in severe neonatal diabetes, and thus, NEUROD1 is required for proper activation of the transcriptional network and differentiation of functional alpha and beta cells.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA19-07378S" target="_blank" >GA19-07378S: Interplay between ISLET1 and NEUROD1 in pancreatic development and disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

1422-0067

Volume of the periodical

22

Issue of the periodical within the volume

13

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

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UT code for WoS article

000671289600001

EID of the result in the Scopus database

2-s2.0-85108258147