NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00576977" target="_blank" >RIV/86652036:_____/23:00576977 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/23:00084167
Result on the web
<a href="https://www.nature.com/articles/s41467-023-41306-6" target="_blank" >https://www.nature.com/articles/s41467-023-41306-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-023-41306-6" target="_blank" >10.1038/s41467-023-41306-6</a>
Alternative languages
Result language
angličtina
Original language name
NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development
Original language description
NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic & beta, cells. Disruption of Neurod1 during pancreatic development causes severe neonatal diabetes, however, the exact role of NEUROD1 in the differentiation programs of endocrine cells is unknown. Here, we report a crucial role of the NEUROD1 regulatory network in endocrine lineage commitment and differentiation. Mechanistically, transcriptome and chromatin landscape analyses demonstrate that Neurod1 inactivation triggers a downregulation of endocrine differentiation transcription factors and upregulation of non-endocrine genes within the Neurod1-deficient endocrine cell population, disturbing endocrine identity acquisition. Neurod1 deficiency altered the H3K27me3 histone modification pattern in promoter regions of differentially expressed genes, which resulted in gene regulatory network changes in the differentiation pathway of endocrine cells, compromising endocrine cell potential, differentiation, and functional properties.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
5554
UT code for WoS article
001066679400001
EID of the result in the Scopus database
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