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NOVEL PSMA-SPECIFIC BINDING PROTEINS

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00563670" target="_blank" >RIV/86652036:_____/22:00563670 - isvavai.cz</a>

  • Result on the web

    <a href="https://worldwide.espacenet.com/patent/search/family/053540662/publication/WO2017005799A1?q=PCT%2FEP2016%2F065993" target="_blank" >https://worldwide.espacenet.com/patent/search/family/053540662/publication/WO2017005799A1?q=PCT%2FEP2016%2F065993</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    NOVEL PSMA-SPECIFIC BINDING PROTEINS

  • Original language description

    The present invention relates to a prostate-specific membrane antigen (PSMA)-specific binding protein, wherein the PSMA-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to PSMA with a KD of 10 nM or lower. The present invention also relates to a nucleic acid molecule encoding the PSMA-specific binding protein of the invention, a vector comprising said nucleic acid molecule of the invention and a host cell transformed with the vector. Furthermore, the invention relates to a method of producing the PSMA-specific binding protein of the invention, the method comprising culturing the host cell of the invention under suitable conditions and isolating the PSMA-specific binding protein produced. The present invention further relates to a protein conjugate comprising the PSMA-specific binding protein of the invention, or the PSMA-specific binding protein produced by the method of the invention. In addition, the present invention relates to a pharmaceutical or diagnostic composition to the PSMA-specific binding protein of the invention, the nucleic acid molecule of the invention, the vector of the invention, the host cell of the invention or the PSMA-specific binding protein produced by the method of the invention, for use in therapy and/or diagnosis, and in particular for use in the therapy and/or diagnosis of tumors, Crohn's disease and/or neurological diseases.

  • Czech name

  • Czech description

Classification

  • Type

    P - Patent

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Patent/design ID

    US 11464877

  • Publisher

    US001 -

  • Publisher name

    United States Patent and Trademark Office (USPTO)

  • Place of publication

    Alexandria

  • Publication country

    US - UNITED STATES

  • Date of acceptance

    Oct 11, 2022

  • Owner name

    Biotechnologický ústav AV ČR, v. v. i., Technische Universitaet Muenchen

  • Method of use

    A - Výsledek využívá pouze poskytovatel

  • Usage type

    A - K využití výsledku jiným subjektem je vždy nutné nabytí licence