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MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00569542" target="_blank" >RIV/86652036:_____/22:00569542 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/22:00128591 RIV/00216208:11310/22:10455235 RIV/60460709:41210/22:91975

  • Result on the web

    <a href="https://www.science.org/doi/10.1126/sciadv.abn0047" target="_blank" >https://www.science.org/doi/10.1126/sciadv.abn0047</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1126/sciadv.abn0047" target="_blank" >10.1126/sciadv.abn0047</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

  • Original language description

    Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10604 - Reproductive biology (medical aspects to be 3)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Science Advances

  • ISSN

    2375-2548

  • e-ISSN

    2375-2548

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    36

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    eabn0047

  • UT code for WoS article

    000911968500004

  • EID of the result in the Scopus database

    2-s2.0-85137506352