MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00569542" target="_blank" >RIV/86652036:_____/22:00569542 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00128591 RIV/00216208:11310/22:10455235 RIV/60460709:41210/22:91975
Result on the web
<a href="https://www.science.org/doi/10.1126/sciadv.abn0047" target="_blank" >https://www.science.org/doi/10.1126/sciadv.abn0047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abn0047" target="_blank" >10.1126/sciadv.abn0047</a>
Alternative languages
Result language
angličtina
Original language name
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
Original language description
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
8
Issue of the periodical within the volume
36
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
eabn0047
UT code for WoS article
000911968500004
EID of the result in the Scopus database
2-s2.0-85137506352