The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00569654" target="_blank" >RIV/86652036:_____/23:00569654 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10458716
Result on the web
<a href="https://journals.asm.org/doi/10.1128/aac.01506-22" target="_blank" >https://journals.asm.org/doi/10.1128/aac.01506-22</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/aac.01506-22" target="_blank" >10.1128/aac.01506-22</a>

Result language
angličtina
Original language name
The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis
Original language description
Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the brain-eating amoeba Naegleria fowleri. A major obstacle is the requirement for drugs with the ability to cross the blood-brain barrier, which are used in extremely high doses, cause severe side effects, and are usually ineffective. We discovered that the 4-aminomethylphenoxy-benzoxaborole AN3057 exhibits nanomolar potency against N. fowleri, and experimental treatment of infected mice significantly prolonged survival and demonstrated a 28% relapse-free cure rate.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/GA20-28072S" target="_blank" >GA20-28072S: Copper homeostasis in pathogenic free-living amoebae</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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