ATG5 as biomarker for early detection of malignant mesothelioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00571546" target="_blank" >RIV/86652036:_____/23:00571546 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10465276 RIV/00216208:11110/23:10465276
Result on the web
<a href="https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-023-06330-1" target="_blank" >https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-023-06330-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13104-023-06330-1" target="_blank" >10.1186/s13104-023-06330-1</a>
Alternative languages
Result language
angličtina
Original language name
ATG5 as biomarker for early detection of malignant mesothelioma
Original language description
ObjectivesMalignant pleural mesothelioma (MPM) is an aggressive disease with grim prognosis due to lack of effective treatment options. Disease prediction in association with early diagnosis may both contribute to improved MPM survival. Inflammation and autophagy are two processes associated with asbestos-induced transformation. We evaluated the level of two autophagic factors ATG5 and HMGB1, microRNAs (miRNAs) such as miR-126 and miR-222, and the specific biomarker of MPM, soluble mesothelin related proteins (Mesothelin) in asbestos-exposed individuals, MPM patients, and healthy subjects. The performance of these markers in detecting MPM was investigated in pre-diagnostic samples of asbestos-subjects who developed MPM during the follow-up and compared for the three groups.ResultsThe ATG5 best distinguished the asbestos-exposed subjects with and without MPM, while miR-126 and Mesothelin were found as a significant prognostic biomarker for MPM. ATG5 has been identified as an asbestos-related biomarker that can help to detect MPM with high sensitivity and specificity in pre-diagnostic samples for up to two years before diagnosis. To utilize this approach practically, higher number of cases has to be tested in order to give the combination of the two markers sufficient statistical power. Performance of the biomarkers should be confirmed by testing their combination in an independent cohort with pre-diagnostic samples.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Research Notes
ISSN
1756-0500
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
61
UT code for WoS article
000975306600002
EID of the result in the Scopus database
2-s2.0-85153687746