RNA localization during early development of the axolotl

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00583145" target="_blank" >RIV/86652036:_____/23:00583145 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10472359
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2023.1260795/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2023.1260795/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2023.1260795" target="_blank" >10.3389/fcell.2023.1260795</a>

Result language
angličtina
Original language name
RNA localization during early development of the axolotl
Original language description
The asymmetric localization of biomolecules is critical for body plan development. One of the most popular model organisms for early embryogenesis studies is Xenopus laevis but there is a lack of information in other animal species. Here, we compared the early development of two amphibian species-the frog X. laevis and the axolotl Ambystoma mexicanum. This study aimed to identify asymmetrically localized RNAs along the animal-vegetal axis during the early development of A. mexicanum. For that purpose, we performed spatial transcriptome-wide analysis at low resolution, which revealed dynamic changes along the animal-vegetal axis classified into the following categories: profile alteration, de novo synthesis and degradation. Surprisingly, our results showed that many of the vegetally localized genes, which are important for germ cell development, are degraded during early development. Furthermore, we assessed the motif presence in UTRs of degraded mRNAs and revealed the enrichment of several motifs in RNAs of germ cell markers. Our results suggest novel reorganization of the transcriptome during embryogenesis of A. mexicanum to converge to the similar developmental pattern as the X. laevis.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology

Project
<a href="/en/project/GA20-23836S" target="_blank" >GA20-23836S: Sturgeon as a unique model for evolutionary transition from holoblastic to meroblastic cleavage pattern, and for endoderm development in vertebrates</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)