Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F24%3A00582380" target="_blank" >RIV/86652036:_____/24:00582380 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/24:00582380 RIV/00216208:11110/24:10480560 RIV/00216208:11310/24:10480560
Result on the web
<a href="https://www.nature.com/articles/s41467-023-44563-7" target="_blank" >https://www.nature.com/articles/s41467-023-44563-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-023-44563-7" target="_blank" >10.1038/s41467-023-44563-7</a>
Alternative languages
Result language
angličtina
Original language name
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
Original language description
Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the level of assembly, a process that leverages metastable assembly intermediates. The nature of these intermediates and how CII subunits transfer between metastable complexes remains unclear. In this work, we identify metastable species containing the SDHA subunit and its assembly factors, and we assign a preferred temporal sequence of appearance of these species during CII assembly. Structures of two species show that the assembly factors undergo disordered-to-ordered transitions without the appearance of significant secondary structure. The findings identify that intrinsically disordered regions are critical in regulating CII assembly, an observation that has implications for the control of assembly in other biomolecular complexes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
473
UT code for WoS article
001141821400002
EID of the result in the Scopus database
2-s2.0-85182102160