Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F15%3A00473328" target="_blank" >RIV/86652079:_____/15:00473328 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications

Original language description

This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EH - Ecology - communities

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Optoelectronics and Advanced Materials

ISSN

1454-4164

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

7-8

Country of publishing house

RO - ROMANIA

Number of pages

12

Pages from-to

1198-1209

UT code for WoS article

000359967600046

EID of the result in the Scopus database

2-s2.0-84944261087