Histone H2A: a promising diagnostic marker in heart failure with reduced versus preserved ejection fraction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F25%3A00639895" target="_blank" >RIV/86652079:_____/25:00639895 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11010-025-05254-7" target="_blank" >https://link.springer.com/article/10.1007/s11010-025-05254-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-025-05254-7" target="_blank" >10.1007/s11010-025-05254-7</a>
Alternative languages
Result language
angličtina
Original language name
Histone H2A: a promising diagnostic marker in heart failure with reduced versus preserved ejection fraction
Original language description
The diagnosis of heart failure with preserved left ventricle ejection fraction (HFpEF) remains a challenge, with score-based algorithms showing varying diagnostic performance and biomarkers sometimes inconclusive. This study aimed to examine whether circulating histones and histone complexes, which recently emerged as robust biomarkers of inflammation and stroke, nshow distinct profiles in plasma from healthy individuals, HF with reduced EF (HFrEF), and HFpEF patients. We evaluated the plasma histone profile of 30 sex/age-matched healthy individuals, 22 HFpEF and 25 HFrEF prior any therapeutic intervention. ImageStreamX-based detection approach was used to measure the levels of circulating particles positive for core nhistones H2A, H2B, H3, H4, histone variants macroH2A1.1 and macroH2A1.2. While we found increased levels of most of the histones and histone complexes in both HFpEF and HFrEF patients, H2A was significantly elevated only in HFpEF, compared to healthy individuals (p-value = 0.002) and to HFrEF (p-value = 0.00008). In line with these findings, H2A showed npositive correlation with EF (r = 0.493). We identified a plasma histone profile able to detect HF and differentiate between HFpEF and HFrEF using a high throughput and imaging flow cytometry-adapted liquid biopsy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
1573-4919
Volume of the periodical
480
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
4343-4354
UT code for WoS article
001449799400001
EID of the result in the Scopus database
2-s2.0-105001055583