Self-Assembled Nanocarriers of Synthetic and Natural Plasmalogens for Potential Nanomedicine Development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2FCZ______%3A_____%2F24%3AN0000031" target="_blank" >RIV/CZ______:_____/24:N0000031 - isvavai.cz</a>
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:001354257100001" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:001354257100001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adtp.202400093" target="_blank" >10.1002/adtp.202400093</a>
Alternative languages
Result language
angličtina
Original language name
Self-Assembled Nanocarriers of Synthetic and Natural Plasmalogens for Potential Nanomedicine Development
Original language description
Plasmalogens are bioactive glycerophospholipids with a vinyl ether bond at the sn-1 position of the glycerol backbone, which imparts free-radical scavenging properties. Amelioration of the plasmalogen levels, which decline with aging, is required for novel metabolic therapies for Parkinson's disease (PD), Alzheimer's disease (AD), and dementia. This work designed, prepared, and in vitro characterized plasmalogen-loaded lipid nanoparticles with neuroprotective potential for neuronanomedicine. Liquid crystalline nanoparticles formed by natural scallop-derived plasmalogens are in vitro evaluated with respect to synthetic docosapentaenoyl (DPA) plasmenyl (vinyl ether) glycerophospholipids, formulated with the helper lipid monoolein (MO). The structural organization of the lipid nanoparticles is characterized by synchrotron small-angle X-ray scattering (SAXS). The employed self-assembly technique yielded plasmalogen-based nanoassemblies of hexosome, cubosome, vesicular, or intermediate topology types. The internalization of fluorescently-labeled nanoparticles in differentiated human neuroblastoma SH-SY5Y cells is followed by flow cytometry. Under the investigated conditions, the scallop-derived plasmalogen nanocarriers significantly influenced the measured mitochondrial membrane potential compared to those involving synthetic plasmalogens with DPA chains. Levels of protein biomarkers, such as brain-derived neurotrophic factor (BDNF), can be regulated depending on the nanocarrier type. The results identified cubosome, hexosome, and vesicular types of plasmalogen nanocarriers presenting antioxidant properties and preserving neuronal cell integrity and viability.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ADVANCED THERAPEUTICS
ISSN
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e-ISSN
2366-3987
Volume of the periodical
2024
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
202400093
UT code for WoS article
001354257100001
EID of the result in the Scopus database
2-s2.0-85208235658