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150 941 (0,204s)

Result

Epigenetic remodeling during arsenical-induced malignant transformation

We evaluated the potential epigenetic component of arsenical action by assessing the histone acetylation state of 13 000 human gene promoters in a cell line model of arsenical-mediated malignant transformation. We show changes in hi...

FD - Onkologie a hematologie

  • 2008
  • Jx
Result

Aspergillus niger decreases bioavailability of arsenic(V) via biotransformation of manganese oxide into biogenic oxalate minerals

of the transformation on mobility and bioavailability of arsenic. Our results showed that the A. niger strain CBS 140837 greatly affected the stability of hausmannite and induced% of manganese was bioextracted, the arsenic...

Environmental biotechnology

  • 2020
  • Jimp
  • Link
Result

Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water

This pilot study examined the feasibility of analyzing As species in cells that originate in the urinary bladder, a target organ for As-induced cancer in humans....

CB - Analytická chemie, separace

  • 2008
  • Jx
Result

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

The paper reviews the results of laboratory studies that examined the effects of iAs on glucose metabolism and describes new experiments in which the diabetogenic effects of iAs exposure were reproduced in a mouse model....

CB - Analytická chemie, separace

  • 2007
  • Jx
Result

Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells

Aberrant DNA methylation participates in carcinogenesis and is a molecular hallmark of a tumor cell. We used a model of arsenical-induced malignant transformation of immortalized human urothelial cells and DNA methylation microarray...

EB - Genetika a molekulární biologie

  • 2009
  • Jx
Result

Two facets of world arsenic problem solution: crop poisoning restriction and enforcement of phytoremediation

in plant ability to cope with arsenic-induced oxidative and nitrosative stresses. on photosynthesis and sugar metabolism as important arsenic targets and simultaneously defence problem all over the world. Arsenic,...

Plant sciences, botany

  • 2018
  • Jimp
  • Link
Result

Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis

Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to a therapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monoblasts induced by arsenic...

BO - Biofyzika

  • 2008
  • Jx
Result

Mitigation of arsenic poisoning induced oxidative stress and genotoxicity by Ocimum gratissimum L

Arsenic toxicity is a major problem across the world due to geogenic activity and has been supposed to generate free radicals and genotoxicity among the arsenic for the arsenic-induced free radical-affecte...

Hematology

  • 2024
  • Jimp
  • Link
Result

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

The insulin producing pancreatic ?-cells are among the targets for As exposure and the inhibition of glucose stimulated insulin secretion by low concentrations of the methylated metabolites of iAs may be the key mechanism of iAs-induced diab...

CB - Analytická chemie, separace

  • 2013
  • Jx
  • Link
Result

The effect of arsenic contamination of environment on plant metabolism

Arsenic (As) is not essential for plant metabolism. In soils, it forms highly phytotoxic. In soil As typically occurs as arsenate (AsV) and arsenite (AsIII, As induces a specific stress metabolism, determines transport and ...

Environmental sciences (social aspects to be 5.7)

  • 2022
  • O
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