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Common structural patterns in the maxicircle divergent region of Trypanosomatidae
Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called maxicircle sequences were available until now. Using PacBio data, we assembl...
Pathology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen
the assembly of the T. lewisi kinetoplast maxicircle DNA, which is a homologue and coding regions. Comparative analysis of the maxicircle sequence of T. lewisi with these parasites, respectively. The high GC content in at least 9 <...
EB - Genetika a molekulární biologie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Kinetoplast Genome of Leishmania spp. Is under Strong Purifying Selection
consists of fairly conserved maxicircle and minicircle molecules that can, nevertheless maxicircles are among the most variable regions of both genomes. In addition, we demonstrate that synonymous substitutions greatly predominate ...
Genetics and heredity (medical genetics to be 3)
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Pam16 and Pam18 were repurposed during Trypanosoma brucei evolution to regulate the replication of mitochondrial DNA
to regulate the replication of maxicircles within the intricate kDNA network, the most of maxicircles, akin to the effects observed for TbPam18 and TbPam16. Moreover, depletion a protein complex comprising TbPam18, TbPam16, and MaR...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Doubts about Trypanosoma equiperdum strains classed as Trypanosoma brucei or Trypanosoma evansi
There is an ambiguity concerning species identity of a number of clinically relevant strains of the above-mentioned Trypanozoon species. We suggest that the species can be assigned only to strains, in which the maxicircle and minicircle kine...
EB - Genetika a molekulární biologie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Trypanosoma brucei: two steps to spread out from Africa
Trypanosoma brucei equiperdum and Trypanosoma brucei evansi are typically considered separate species, although a recent study suggested that these organisms can be classified as subspecies of Trypanosoma brucei, which we also favor. Here we present ...
EB - Genetika a molekulární biologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid Vickermania
The trypanosomatid flagellates possess in their single mitochondrion a highly complex kinetoplast (k)DNA, which is composed of interlocked circular molecules of two types. Dozens of maxicircles represent a classical mitochondrial genome and ...
Biochemistry and molecular biology
- 2025 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Mitochondrial histone-like DNA-binding proteins are essential for normal cell growth and mitochondrial function in Crithidia fasciculata
of the sequence encoding the entire KAP2 and KAP3 locus increases maxicircle mRNA levels two...
EB - Genetika a molekulární biologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Unusual mitochondrial genome structures throughout the Euglenozoa
Mitochondrial DNA of Kinetoplastea is composed of different chromosomes, the maxicircle (bearing so-called regular genes) and numerous minicircles (specifying guide RNAs involved in RNA editing). In trypanosomes [Kinetoplastea], DNA circles ...
EB - Genetika a molekulární biologie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Mitochondrial genomes of Excavata
of maxicircles and minicircles...
Genetics and heredity (medical genetics to be 3)
- 2018 •
- C •
- Link
Rok uplatnění
C - Kapitola v odborné knize
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