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21 768 (0,096s) •

Result

Effect of acetyl-L-carnitine on the anticholinesterase activity of 7-methoxytacrine in vivo

Repeated administration of acetyl-L-carnitine did not influence anticholinesterase activity of 7-methoxytacrine in the frontal cortex, hippocampus and basal ganglia, moreover, the inhibitory effect of 7-methoxytacrine

CE - Biochemie

  • 2001
    • •
  • Jx
Result

Influence of L-carnitine on biodistribution and effect of 7-methoxytacrine in rat

The main topic of the project is the experimental search for the anticholinesterase activity of 7-methoxytacrine in selected brain structures and in the some peripheral organs and tissues. The interaction of 7-methoxyta...

FP - Ostatní lékařské obory

  • 2001
    • •
  • Jx
Result

The effect of 7-methoxytacrine of EEG in healthy volunteers.

Annotation not available...

ED - Fyziologie

  • 1993
    • •
  • Jx
Result

The influence of the markers of cholinergic transmission by 7-methoxytacrine and 1-carnitine

FR - Farmakologie a lékárnická chemie

  • 1998
    • •
  • Jx
Result

Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease

In this paper, series of 7-MEOTA analogues (N-alkyl-7-methoxytacrine) were synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (AChE) and plasmatic human butyrylcholinesterase (BChE...

FR - Farmakologie a lékárnická chemie

  • 2010
    • •
  • Jx
Result

Preparation of 7-Methoxy Tacrine Dimer Analogs and Their In vitro/In silico Evaluation as Potential Cholinesterase Inhibitors

Novel types of symmetric bis-7-methoxytacrines connected by oligoethyleneoxy chains 3-5 and nonsymmetric monomeric 7-methoxytacrines containing hydroxyl (hBChE) were compared, with 7-MEOTA (2) as the stand...

FR - Farmakologie a lékárnická chemie

  • 2015
    • •
  • Jx
    • •
  • Link
Result

Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs

mostly due to the risk of hepatotoxicity and might be replaced by its derivate 7-methoxytacrine(7-MEOTA). The aim of this study was to assess the impact of these two) entered the study. A single dose of tacrine (200 mg i.m...

FE - Ostatní obory vnitřního lékařství

  • 2015
    • •
  • Jx
Result

Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer's disease

A series of cholinesterase inhibitors acting as dual binding site heterodimers for the management of Alzheimer's disease were developed. The series of 7-methoxytacrine (7-MEOTA/butyryl cholinesterase (hAChE, hBChE) and comp...

FR - Farmakologie a lékárnická chemie

  • 2015
    • •
  • Jx
    • •
  • Link
Result

New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine

7-methoxy derivate (7-MEOTA) that has not been marketed. We determined the IC50 (6.67+/-0.92)x10-7 M for tacrine and (1.66+/-1.43)x10-9 M for 7-MEOTA. In this in vitro study, 7-MEOTA acts as stronger inhi...

FP - Ostatní lékařské obory

  • 2008
    • •
  • Jx
Result

Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties

, short half-life and liver toxicity. 7-methoxytacrine (7-MEOTA) is equally isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described....

FH - Neurologie, neurochirurgie, neurovědy

  • 2011
    • •
  • Jx
    • •
  • Link
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