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*Investigation of novel formulations of gels containing liposomes fused wiht hydrophobic microparticles of phtalocyanine for photodynamic therapy of tumors

Project goals

*Investigate formulations; means of stabilization of gel containing liposomes and hydrophobic phtalocyanine; preclinically test its efficiency on various tumor types and till stage 2B clinically test this new drug form for photodynamic therapy of tumors.

Keywords

Liposomal gel for tumor therapyphatolocyaninephotodynamic therapy of tumorsnovel drug formulations

Public support

  • Provider

    Ministry of Industry and Trade

  • Programme

    Sustainable welfare

  • Call for proposals

    Trvalá prosperita 1 (SMPO200600001)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    2A-1TP1/026

Alternative language

  • Project name in Czech

    *Výzkum nové lékové formy gelu s liposomy zfúzovanými s hydrofóbními mikročásticemi ftalocyaninu pro fotodynamickou léčbu zhoubných nádorů.

  • Annotation in Czech

    *Vyzkoumá možnosti formulací, prostředky stabilizace gelové formy s liposomy a hydrofóbním ftalocy-aminem; preklinicky otestuje účinnost na různé typy tumorů a do stadia 2B klinicky otestuje získaný lék (fotosenzitizátor) pro fotodynamickou terapii tumorů

Scientific branches

  • R&D category

    VV - Exeperimental development

  • CEP classification - main branch

    FR - Pharmacology and apothecary chemistry

  • CEP - secondary branch

    FD - Oncology and haematology

  • CEP - another secondary branch

  • 30104 - Pharmacology and pharmacy
    30204 - Oncology
    30205 - Hematology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    We have developed certificed methodology for manufacturing of liposomal gel with hydrophobic phthalocyanine and tested its efficiancy on human tumors implanted to athymic nude mice. The preparation exhibited high efficiency after 10 min application.

Solution timeline

  • Realization period - beginning

    Nov 15, 2006

  • Realization period - end

    Dec 31, 2011

  • Project status

    U - Finished project

  • Latest support payment

    May 26, 2011

Data delivery to CEP

  • Confidentiality

    C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

  • Data delivery code

    CEP12-MPO-2A-U/01:1

  • Data delivery date

    Jul 23, 2012

Finance

  • Total approved costs

    19,703 thou. CZK

  • Public financial support

    13,598 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    6,108 thou. CZK

Recognised costs

19 703 CZK thou.

Public support

13 598 CZK thou.

0%


Provider

Ministry of Industry and Trade

CEP

FR - Pharmacology and apothecary chemistry

Solution period

15. 11. 2006 - 31. 12. 2011