Pathophysiology of dystonia – role of gene-environment interaction and common pathophysiological pathways
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
—
Main participants
Univerzita Karlova / 1. lékařská fakulta
Contest type
M2 - International cooperation
Contract ID
MSMT-21745/2020
Alternative language
Project name in Czech
Pathophysiology of dystonia – role of gene-environment interaction and common pathophysiological pathways
Annotation in Czech
The EurDyscover consortium combines outstanding expertise from across Europe in molecular neurobiology, cellular and system pathophysiology, and behavioural and clinical neurosciences to a) explore disease mechanisms and identify common (and novel) pathophysiologic pathways from the molecular to the brain network level using genetically and phenotypically relevant mouse models of genetically divergent dystonias (DYT1, DYT6, DYT25); b) analyse the pathophysiology and disease progression of monogenic and sporadic dystonia in patients by identification of clinical biomarkers; c) support the current clinical diagnosis of dystonia by molecular biomarkers derived from multi-omic approaches comparing mouse tissue with accessible human material from dystonia patients. Multi-omic, fMRI, MEG, TMS, LFP, LTP/LTD, PAS, optogenetics and in-vivo calcium imaging will be used to characterise brain network changes in rodent models and human dystonia.
Scientific branches
R&D category
AP - Applied research
OECD FORD - main branch
30502 - Other medical science
OECD FORD - secondary branch
—
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
FP - Other medical fields
Solution timeline
Realization period - beginning
Jul 1, 2020
Realization period - end
Aug 31, 2024
Project status
B - Running multi-year project
Latest support payment
May 19, 2022
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP23-MSM-8F-R
Data delivery date
Apr 19, 2023
Finance
Total approved costs
5,217 thou. CZK
Public financial support
5,217 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK