Molecular mechanisms of sex differences in cardiac metabolism
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Fyziologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-22566S
Alternative language
Project name in Czech
Molecular mechanisms of sex differences in cardiac metabolism
Annotation in Czech
Heart disease is the leading cause of death worldwide, with significant differences in symptoms and outcomes between males and females. Emerging evidence shows that sex chromosomes play a key role in these differences, yet the molecular mechanisms are not known. My research will bridge this knowledge gap by integrating transcriptomic, proteomic, and metabolomic approaches in genetically engineered mouse models. Using mice with genetically tagged mitochondria, we will map the molecular sex differences in healthy heart tissues, cardiomyocytes, and mitochondria, creating a more holistic model of cardiac sex differences. Leveraging a mouse model with a variable number of sex chromosomes, we will define the role of the inactive X chromosome (Xi) in sex-differential cardiac phenotypes, including mitochondrial energy metabolism. Understanding how Xi regulates these differences - providing cardioprotection to one sex while posing a risk to the other - is essential for advancing basic and clinical research, to develop more effective treatments that equally benefit male and female patients.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30201 - Cardiac and Cardiovascular systems
OECD FORD - secondary branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
FA - Cardiovascular diseases including cardio-surgery<br>FB - Endocrinology, diabetology, metabolism, nutrition
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 21, 2026
Finance
Total approved costs
14,172 thou. CZK
Public financial support
14,132 thou. CZK
Other public sources
40 thou. CZK
Non public and foreign sources
0 thou. CZK