Targeting NOX4 in Multiple Organs: A Strategy to Combat Type 2 Diabetes Development
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Fyziologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20409S
Alternative language
Project name in Czech
Targeting NOX4 in Multiple Organs: A Strategy to Combat Type 2 Diabetes Development
Annotation in Czech
Type 2 diabetes (T2DM) is a systemic metabolic disease characterized by chronic hyperglycemia and oxidative stress that drives progressive multi-organ dysfunction. This project targets NOX4, a constitutively active NADPH oxidase isoform, as a key regulator of redox imbalance in obesity-driven T2DM. We aim to elucidate the impact of NOX4-ROS signaling on the function of pancreas, adipose tissue, heart, and bone during obesity-induced T2DM development using pharmacological approaches and knockout models with respect to sex differences. In parallel, we will investigate how NOX4 signaling interacts with RNA methylation (m6A/m6Am) – an emerging epitranscriptomic mechanism implicated in metabolic stress responses. By integrating redox biology with RNA epigenetics, this project will reveal tissue- and sex-specific pathways contributing to T2DM onset and complications. The findings will identify critical windows for NOX4-targeted therapy and provide mechanistic insight into transcriptomic plasticity as a driver of disease progression.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
FB - Endocrinology, diabetology, metabolism, nutrition
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 27, 2026
Finance
Total approved costs
14,444 thou. CZK
Public financial support
14,298 thou. CZK
Other public sources
146 thou. CZK
Non public and foreign sources
0 thou. CZK