NOX4 signaling in pancreatic β-cells: Secrets hidden in the endoplasmic reticulum
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Fyziologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20384S
Alternative language
Project name in Czech
NOX4 signaling in pancreatic β-cells: Secrets hidden in the endoplasmic reticulum
Annotation in Czech
NADPH oxidase isoform 4 activity is key for redox signaling in pancreatic β-cells. Our data show that NOX4 deficiency impairs insulin secretion, increases proinsulin production, and promotes lipid accumulation under physiological conditions upon glucose stimulation. Preliminary findings indicate that glucose-induced NOX4-mediated redox signaling primarily targets the endoplasmic reticulum, with lipid accumulation probably arising as an adaptive response to ER stress caused by NOX4 loss. We propose to functionally validate the protein targets of NOX4-derived redox signaling and investigate how ER stress impacts lipid turnover, and derived post-translational modifications such as S-acylation directly targeting insulin secretion. This work aims to redefine NOX4's role in β-cell function by linking redox signaling with ER homeostasis, lipid metabolism, and insulin secretion. The findings are expected to provide critical insights into metabolic disease mechanisms and identify novel therapeutic strategies for preserving β-cell health.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10601 - Cell biology
OECD FORD - secondary branch
—
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 27, 2026
Finance
Total approved costs
12,448 thou. CZK
Public financial support
12,326 thou. CZK
Other public sources
122 thou. CZK
Non public and foreign sources
0 thou. CZK