Melatonin in human cardiomyocytes: cellular functions in normal cells and heart failure model
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Masarykova univerzita / Lékařská fakulta
Contest type
VS - Public tender
Contract ID
26-22811S
Alternative language
Project name in Czech
Melatonin in human cardiomyocytes: cellular functions in normal cells and heart failure model
Annotation in Czech
Cell death accelerated by hereditary dystrophin mutations is a major cause of heart failure and premature death in patients. In the search for new therapeutic approaches, we found that upregulation of NOS worsens the phenotype of dystrophin-deficient human pluripotent stem cells. At the same time, the close link between dystrophin, the dystrophin-glycoprotein complex and circadian clockwork was shown. In this project, we aim to test whether the activity of circadian synchronizer melatonin can alter the progression of the phenotype of the hiPSC model of Duchenne dystrophy. We also aim to exploit melatonin as an antioxidant that upregulates protective enzymes of redox metabolism and scavenges reactive oxygen species and to test the direct protective effect of melatonin on our cell models in standard media and in high glucose environment. The project includes the assessment of melatonin production by the cells. This project combines the applicant's long-standing interest in the circadian rhythms and melatonin with the co-applicant's unique cardiomyocytes hiPSC model.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 4, 2026
Finance
Total approved costs
9,033 thou. CZK
Public financial support
8,669 thou. CZK
Other public sources
364 thou. CZK
Non public and foreign sources
0 thou. CZK