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Role of Mmi1 in redistribution of Cdc14 phosphataseand stress-induced fragmentation of mitochondria

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

  • Call for proposals

    FP6-2002-Mobility-10

  • Main participants

    Mikrobiologický ústav AV ČR, v. v. i.

  • Contest type

    RP - Co-financing of EC programme

  • Contract ID

    MSMT-502/2016-1

Alternative language

  • Project name in Czech

    Role of Mmi1 in redistribution of Cdc14 phosphataseand stress-induced fragmentation of mitochondria

  • Annotation in Czech

    There is growing evidence that in times of stress there is an intense cross-talk between mitochondria and the nucleus. This cross-talk leads to a “life or death” decision. Yeast protein Mmi1 is a homolog of the mammalian "translationally controlled tumor protein" (TCTP), which plays a critical role in controlling cell survival. We found that in heat-stress cells Mmi1 relocalizes into the nucleus, but also associates with stress granules and mitochondria. We proved that Mmi1 significantly affects proteasome degradation. Our preliminary data revealed that Mmi1 affects distribution of phosphatase Cdc14 and possibly also the function of Cdc14 in controlling the cell cycle and stress induced fragmentation of mitochondria. In this project we would like to address a function of Mmi1 in controlling Cdc14 fate and functions. We aim to elucidate the following questions: What is a role of Mmi1 in controlling Cdc104 redistribution upon normal growth conditions and heat-stress at 40°C? We assume that results from the study on yeast will contribute to better understanding general aspects of a TCTP function in and stress survival and cell fate controls of any eukaryotic cell.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    CE - Biochemistry

  • CEP - another secondary branch

    EA - Morphology and cytology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10601 - Cell biology<br>10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology<br>10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    This project was being realized in the framework of the MOBILITY Activity that aims primarily on establishing and strenghtening ties with foreign research institutions. The control of particular outputs is not implemented by the evalution committee, but the correctness of allocated finances and the adequacy of their use are checked.

Solution timeline

  • Realization period - beginning

    Jan 1, 2016

  • Realization period - end

    Dec 31, 2017

  • Project status

    U - Finished project

  • Latest support payment

    Feb 22, 2017

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP18-MSM-7A-U/02:1

  • Data delivery date

    Jun 8, 2018

Finance

  • Total approved costs

    152 thou. CZK

  • Public financial support

    152 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK