Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms

Provider

Ministry of Education, Youth and Sports

Programme

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Call for proposals

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Main participants

Masarykova univerzita / Středoevropský technologický institut

Contest type

M2 - International cooperation

Contract ID

31177/2022

Project name in Czech

Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms

Annotation in Czech

1. Spatiotemporal analysis of neuronal, glial and immune cell responses at transcriptome and proteome level in vulnerable and more resistant brain regions; 2. Multi-omic bioinformatics analysis of spatiotemporal gene and protein expression changes, supported by systems biology approaches; 3.Multiplexing-based interrogation and validation of identified signatures and master regulators in clinical samples and integration with clinical, neuropathological, and genomic (e.g., GBA and HLA-R genetic variants) heterogeneity in PD.

R&D category

ZV - Basic research

OECD FORD - main branch

30502 - Other medical science

OECD FORD - secondary branch

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OECD FORD - another secondary branch

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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

FP - Other medical fields

Realization period - beginning

May 1, 2024

Realization period - end

Apr 30, 2027

Project status

B - Running multi-year project

Latest support payment

Jun 18, 2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP25-MSM-9F-R

Data delivery date

Feb 20, 2025

Total approved costs

6,633 thou. CZK

Public financial support

6,633 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

0 thou. CZK