Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms
Project goals
1. Spatiotemporal analysis of neuronal, glial and immune cell responses at transcriptome and proteome level in vulnerable and more resistant brain regions; 2. Multi-omic bioinformatics analysis of spatiotemporal gene and protein expression changes, supported by systems biology approaches; 3.Multiplexing-based interrogation and validation of identified signatures and master regulators in clinical samples and integration with clinical, neuropathological, and genomic (e.g., GBA and HLA-R genetic variants) heterogeneity in PD.
Keywords
α-synucleinvulnerabilityspatial transcriptomicssingle cell profilingnetwork analysisgenome scale modellin
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
—
Main participants
Masarykova univerzita / Středoevropský technologický institut
Contest type
M2 - International cooperation
Contract ID
31177/2022
Alternative language
Project name in Czech
Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms
Annotation in Czech
1. Spatiotemporal analysis of neuronal, glial and immune cell responses at transcriptome and proteome level in vulnerable and more resistant brain regions; 2. Multi-omic bioinformatics analysis of spatiotemporal gene and protein expression changes, supported by systems biology approaches; 3.Multiplexing-based interrogation and validation of identified signatures and master regulators in clinical samples and integration with clinical, neuropathological, and genomic (e.g., GBA and HLA-R genetic variants) heterogeneity in PD.
Scientific branches
Solution timeline
Realization period - beginning
May 1, 2024
Realization period - end
Apr 30, 2027
Project status
B - Running multi-year project
Latest support payment
Jun 18, 2024
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP25-MSM-9F-R
Data delivery date
Feb 20, 2025
Finance
Total approved costs
6,633 thou. CZK
Public financial support
6,633 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
6 633 CZK thou.
Public support
6 633 CZK thou.
100%
Provider
Ministry of Education, Youth and Sports
OECD FORD
Other medical science
Solution period
01. 05. 2024 - 30. 04. 2027